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KMID : 0438219730100010411
Korea University Medical Journal
1973 Volume.10 No. 1 p.411 ~ p.422
Immunohistochemical Studies on the Prolactin Cells of Rat Pituitary Gland During Pregnancy and Lactation


Abstract
A study of the prolactin cells of the rat pituitary gland has been presented. Serial sections of sixty pituitary glands from the pregnant and post partum rats of various period have been reacted with specific rabbit anti-prolactin and horseradish peroxidase labeled sheep anti-rabbit gamma globulin. Prolactin cells from 240 representative visual fields per group were counted under the higher magnification of light microscope and the following results were obtained.
1. There was sharp rising of number of prolactin cells in post partum lactating rats, while non-lactating group of post partum rats showed gradual decrease of cell number which revert almost to that of the pregnancy level.
2. Prolactin cells were more numerous in 2-day lactating rats than any other group of rats. It have increased by almost twice the number presented in control and pregnant rats.
3. No significant changes of cell number were observed in the pregnant group compared with the control group.
4. Although there were significant changes in prolactin cell number between post partum lactating and non-lactating rats, luteinizing hormone cells revealed little change.
5. Increment of prolactin cells seem to be occured evenly throughout the anterior lobe of pituitary gland.
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